Professor Ewan Pearson
Head of Division, Population Health & Genomics, School of Medicine, University of Dundee, UK
Ewan Pearson is Professor of Diabetic Medicine at the University of Dundee, Visiting Professor at the University of Edinburgh, Guest Professor at University of Lund and Honorary Consultant in Diabetes and Endocrinology at Ninewells Hospital and Medical School in Dundee. In the School of Medicine he is the Head of Division, Population Health & Genomics, and the Director of the Dundee Clinical Academic Track. He leads the IMI-DIRECT project on stratification in type 2 diabetes and is strand 2 lead on the ABPI-MRC funded MASTERMIND project. He is an Associate Director for the Health Data Research-UK Scotland substantive site. Ewan has been awarded the Royal College of Physicians of Edinburgh Croom Lecture, an EASD Rising Star award, the Diabetes UK RD Lawrence Lecture and Dorothy Hodgkin Lecture, and the EASD Minkowski Award.
The Pearson group’s research interests have been in the phenotypic and genotypic determinants of drug response in diabetes, and in stratified approaches to the management of diabetes. Using the extensive prescribing and health record data linked to the GoDARTS bioresource the group have identified novel variants associated with glycaemic response to metformin at the ATM locus and at a variant altering expression of GLUT2. Ongoing work is on genomics of response to sulphonylureas, GLP-1RA and SGLT2i. The Pearson group also undertake recruit by genotype human physiology studies – with recent work using insights from monogenic diabetes to establish novel physiological mechanisms for low dose sulphonylureas.