Martina Muckenthaler

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9) Publications

1. Mühlfeld C, Neves J, Brandenberger C, Hegermann J, Wrede C, Altamura S, Muckenthaler MU: Air-blood barrier thickening and alterations of alveolar epithelial type 2 cells in mouse lungs with disrupted hepcidin/ferroportin regulatory system. Histochem Cell Biol. 2018

2. Traeger L, Gallitz I, Sekhri R, Bäumer N, Kuhlmann T, Kemming C, Holtkamp M, Müller JC, Karst U, Canonne-Hergaux F, Muckenthaler MU, Bloch DB, Olschewski A, Bartnikas TB, Steinbicker AU: ALK3 undergoes ligand-independent homodimerization and BMP-induced heterodimerization with ALK2. Free Radic Biol Med. 2018, 129:127-137.

3. Artuso I, Lidonnici MR, Altamura S, Mandelli G, Pettinato M, Muckenthaler MU, Silvestri L, Ferrari G, Camaschella C, Nai A: Transferrin receptor 2 is a potential novel therapeutic target for β- thalassemia: evidence from a murine model. Blood. 2018, 132(21):2286-2297

4. Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA: Dietary stearic acid regulates mitochondria in vivo in humans. Nat Commun. 2018, 7;9(1):3129

5. Cordas Dos Santos DM, Eilers J, Sosa Vizcaino A, Orlova E, Zimmermann M, Stanulla M, Schrappe M, Börner K, Grimm D, Muckenthaler MU, Kulozik AE, Kunz JB: MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB. BMC Cancer 2018, 18;18(1):663

6. Lim D, Kim KS, Jeong JH, Marques O, Kim HJ, Song M, Lee TH, Kim JI, Choi HS, Min JJ, Bumann D, Muckenthaler MU, Choy HE: The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages. Nat Commun. 2018, 29;9(1):2091

7. Stanulla M, Dagdan E, Zaliova M, Möricke A, Palmi C, Cazzaniga G, Eckert C, Te Kronnie G, Bourquin JP, Bornhauser B, Koehler R, Bartram CR, Ludwig WD, Bleckmann K, Groeneveld-Krentz S, Schewe D, Junk SV, Hinze L, Klein N, Kratz CP, Biondi A, Borkhardt A, Kulozik A, Muckenthaler MU, Basso G, Valsecchi MG, Izraeli S, Petersen BS, Franke A, Dörge P, Steinemann D, Haas OA, Panzer-Grümayer R, Cavé H, Houlston RS, Cario G, Schrappe M, Zimmermann M; TRANSCALL Consortium; International BFM Study Group: IKZF1plus Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia. J Clin Oncol. 2018, 36(12):1240-1249

8. Lai D, Teng F, Hammad S, Werle J, Maas T, Teufel A, Muckenthaler MU, Dooley S, Vujić Spasić M: Hepatic Smad7 overexpression causes severe iron overload in mice. Blood. 2018, 131(5):581- 585

9. Wiedenmann T, Dietrich N, Fleming T, Altamura S, Deelman LE, Henning RH, Muckenthaler MU, Nawroth PP, Hammes HP, Wagner AH, Hecker M: Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice. J Diabetes Complications. 2018,

32(2):130-138

10. Vinchi F, Sparla R, Simmelbauer A, Altamura S, Speich S, Galy B, Hentze MW, Muckenthaler MU: Low-iron diet and chelation therapy rescue severe atherosclerosis associated with high circulating iron levels. Atherosclerosis 2017, 263: e15-e16

11. Vinchi F, Vercellotti GM, Belcher JD, Sparla R, Fibach E, Zreid H, Rasras R, Ghoti H, Muckenthaler MU, Rachmilewitz EA: Elevated systemic heme and iron levels as risk factor for vascular dysfunction and atherosclerosis: Evidence from a beta-thalassemia cohort study. Atherosclerosis 2017, 263:

e107-e108

12. Costa da Silva M, Breckwoldt MO, Vinchi F, Correia MP, Stojanovic A, Thielmann CM, Meister M, Muley T, Warth A, Platten M, Hentze MW, Cerwenka A, Muckenthaler MU: Iron induces anti-tumor activity in tumor-associated macrophages. Front Immunol 2017, 8: 1479

13. Altamura S, Kopf S, Schmidt J, Mudder K, da Silva AR, Nawroth P, Muckenthaler MU: Uncoupled iron homeostasis in type 2 diabetes mellitus. J Mol Med 2017, (Berl) 95: 1387-1398

14. Pasricha SR, Lim PJ, Duarte TL, Casu C, Oosterhuis D, Mleczko-Sanecka K, Suciu M, Da Silva AR, Al-Hourani K, Arezes J, McHugh K, Gooding S, Frost JN, Wray K, Santos A, Porto G, Repapi E, Gray N, Draper SJ, Ashley N, Soilleux E, Olinga P, Muckenthaler MU, Hughes JR, Rivella S, Milne TA, Armitage AE, Drakesmith H: Hepcidin is regulated by promoter-associated histone acetylation and hdac3. Nat Commun, 2017 8: 403

15. Metzendorf C, Zeigerer A, Seifert S, Sparla R, Najafi B, Canonne-Hergaux F, Zerial M, Muckenthaler MU: Acute loss of the hepatic endo-lysosomal system in vivo causes compensatory changes in iron homeostasis. Sci Rep 2017, 7: 4023

16. da Silva AR, Neves J, Mleczko-Sanecka K, Tandon A, Sauer SW, Hentze MW, Muckenthaler MU: Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin. J Mol Med (Berl) 2017, 95: 851-860

17. Neves J, Leitz D, Kraut S, Brandenberger C, Agrawal R, Weissmann N, Muhlfeld C, Mall MA, Altamura S, Muckenthaler MU: Disruption of the hepcidin/ferroportin regulatory system causes pulmonary iron overload and restrictive lung disease. EBioMedicine 2017, 20: 230-239

18. Brings S, Fleming T, Freichel M, Muckenthaler MU, Herzig S, Nawroth PP: Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention. Int J Mol Sci 2017, 18

19. Vendramini E, Giordan M, Giarin E, Michielotto B, Fazio G, Cazzaniga G, Biondi A, Silvestri D, Valsecchi MG, Muckenthaler MU, Kulozik AE, Gattei V, Izraeli S, Basso G, Te Kronnie G: High expression of mir-125b-2 and snord116 noncoding rna clusters characterize erg-related b cell precursor acute lymphoblastic leukemia. Oncotarget 2017, 8: 42398-42413

20. Steinkellner H, Singh HN, Muckenthaler MU, Goldenberg H, Moganty RR, Scheiber-Mojdehkar B, Sturm B: No changes in heme synthesis in human friedreich s ataxia erythroid progenitor cells. Gene 2017, 621: 5-11

21. Mleczko-Sanecka K, da Silva AR, Call D, Neves J, Schmeer N, Damm G, Seehofer D, Muckenthaler MU: Imatinib and spironolactone suppress hepcidin expression. Haematologica 2017, 102: 1173-1184

22. Hof J, Kox C, Groeneveld-Krentz S, Bandapalli OR, Karawajew L, Schedel K, Kunz JB, Eckert C, Ludwig WD, Ratei R, Rhein P, Henze G, Muckenthaler MU, Kulozik AE, von Stackelberg A, Kirschner-Schwabe R: Notch1 mutation, tp53 alteration and myeloid antigen expression predict outcome heterogeneity in children with first relapse of t-cell acute lymphoblastic leukemia. Haematologica 2017, 102: e249-e252

23. Hollerer I, Bachmann A, Muckenthaler MU: Pathophysiological consequences and benefits of hfe mutations: 20 years of research. Haematologica 2017, 102: 809-817

24. Uras IZ, Scheicher RM, Kollmann K, Glosmann M, Prchal-Murphy M, Tigan AS, Fux DA, Altamura S, Neves J, Muckenthaler MU, Bennett KL, Kubicek S, Hinds PW, von Lindern M, Sexl V: Cdk6 contributes to cytoskeletal stability in erythroid cells. Haematologica 2017, 102: 995-1005

25. Richter-Pechanska P, Kunz JB, Hof J, Zimmermann M, Rausch T, Bandapalli OR, Orlova E, Scapinello G, Sagi JC, Stanulla M, Schrappe M, Cario G, Kirschner-Schwabe R, Eckert C, Benes V, Korbel JO, Muckenthaler MU, Kulozik AE: Identification of a genetically defined ultra-high-risk group in relapsed pediatric t-lymphoblastic leukemia. Blood Cancer 2017, J 7: e523

26. Muckenthaler MU, Rivella S, Hentze MW, Galy B: A red carpet for iron metabolism. Cell 2017, 168: 344-361

27. Frismantas V, Dobay MP, Rinaldi A, Tchinda J, Dunn SH, Kunz J, Richter-Pechanska P, Marovca B, Pail O, Jenni S, Diaz-Flores E, Chang BH, Brown TJ, Collins RH, Uhrig S, Balasubramanian GP, Bandapalli OR, Higi S, Eugster S, Voegeli P, Delorenzi M, Cario G, Loh ML, Schrappe M, Stanulla M, Kulozik AE, Muckenthaler MU, Saha V, Irving JA, Meisel R, Radimerski T, Von Stackelberg A, Eckert C, Tyner JW, Horvath P, Bornhauser BC, Bourquin JP: Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia. Blood 2017, 129: e26-e37

28. Enculescu M, Metzendorf C, Sparla R, Hahnel M, Bode J, Muckenthaler MU, Legewie S: Modelling systemic iron regulation during dietary iron overload and acute inflammation: Role of hepcidin-independent mechanisms. PLoS Comput Biol 2017, 13: e1005322

29. Tagliaferri L, Kunz JB, Happich M, Esposito S, Bruckner T, Hubschmann D, Okun JG, Hoffmann GF, Schulz A, Kappe J, Speckmann C, Muckenthaler MU, Kulozik AE: Newborn screening for severe combined immunodeficiency using a novel and simplified method to measure t-cell excision

circles (trec). Clin Immunol. 2017, 175: 51-55

30. Kirschbaum K, Sonner JK, Zeller MW, Deumelandt K, Bode J, Sharma R, Kruwel T, Fischer M, Hoffmann A, Costa da Silva M, Muckenthaler MU, Wick W, Tews B, Chen JW, Heiland S, Bendszus M, Platten M, Breckwoldt MO:In vivo nanoparticle imaging of innate immune cells can

serve as a marker of disease severity in a model of multiple sclerosis. Proc Natl Acad Sci U S A 2016 113:13227-13232

31. Greil J, Verga-Falzacappa MV, Echner NE, Behnisch W, Bandapalli OR, Pechanska P, Immenschuh S, Vijayan V, Balla J, Tsukahara H, Schneider M, Janka G, Claus M, Longerich T, Muckenthaler MU, Kulozik AE: Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation. Haematologica 2016, 101:e436-e439

32. Kim DK, Kim YH, Jung YS, Kim KS, Jeong JH, Lee YS, Yuk JM, Oh BC, Choy HE, Dooley S, Muckenthaler MU, Lee CH, Choi HS: Orphan nuclear receptor shp regulates iron metabolism  through inhibition of bmp6-mediated hepcidin expression. Sci Rep 2016, 6:34630

33. Green T, Bron D, Chomienne C, de Wit TD, de Haas F, Engert A, Hagenbeek A, Jager U, MacIntyre E, Muckenthaler MU, Smand C, Sonneveld P: Costs of haematological disease high and rising. Lancet Haematol 2016, 3:e353-354

34. Palmi C, Savino AM, Silvestri D, Bronzini I, Cario G, Paganin M, Buldini B, Galbiati M, Muckenthaler MU, Bugarin C, Della Mina P, Nagel S, Barisone E, Casale F, Locatelli F, Lo Nigro L, Micalizzi C, Parasole R, Pession A, Putti MC, Santoro N, Testi AM, Ziino O, Kulozik AE, Zimmermann M, Schrappe M, Villa A, Gaipa G, Basso G, Biondi A, Valsecchi MG, Stanulla M, Conter V, Te Kronnie G, Cazzaniga G: Crlf2 over-expression is a poor prognostic marker in children with high risk t-cell acute lymphoblastic leukemia. Oncotarget 2016, 7:59260-59272

35. Chen S, Feng T, Vujic Spasic M, Altamura S, Breitkopf-Heinlein K, Altenoder J, Weiss TS, Dooley S, Muckenthaler MU: Transforming growth factor beta1 (tgf-beta1) activates hepcidin mrna expression in hepatocytes. J Biol Chem 2016, 291:13160-13174

36. Vinchi F, Costa da Silva M, Ingoglia G, Petrillo S, Brinkman N, Zuercher A, Cerwenka A, Tolosano E, Muckenthaler MU: Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease. Blood 2016, 127:473-486

37. Vinchi F, Costa da Silva M, Ingoglia G, Petrillo S, Brinkman N, Zuercher A, Cerwenka A, Tolosano E, Muckenthaler MU: Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease. Blood 2016, 127:473-486

38. Kunz JB, Awad S, Happich M, Muckenthaler L, Lindner M, Gramer G, Okun JG, Hoffmann GF, Bruckner T, Muckenthaler MU, Kulozik AE: Significant prevalence of sickle cell disease in southwest germany: Results from a birth cohort study indicate the necessity for newborn screening. Ann Hematol. 2016, 95:397-402

39. Babu KR, Muckenthaler MU: Mir-20a regulates expression of the iron exporter ferroportin in lung cancer. J Mol Med (Berl) 2016, 94:347-359

40. Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, Galy B, Hentze M, Muckenthaler MU, Dunaief JL: Mice with hepcidin-resistant ferroportin accumulate iron in the retina. FASEB J

2016, 30:813-823

41. Jaekel N, Lieder K, Albrecht S, Leismann O, Hubert K, Bug G, Kroger N, Platzbecker U, Stadler M, de Haas K, Altamura S, Muckenthaler MU, Niederwieser D, Al-Ali HK: Efficacy and safety of deferasirox in non-thalassemic patients with elevated ferritin levels after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2016, 51:89-95

42. Matsuo S, Ogawa M, Muckenthaler MU, Mizui Y, Sasaki S, Fujimura T, Takizawa M, Ariga N, Ozaki H, Sakaguchi M, Gonzalez FJ, Inoue Y: Hepatocyte nuclear factor 4alpha controls iron metabolism and regulates transferrin receptor 2 in mouse liver. J Biol Chem 2015, 290: 30855- 30865

43. Kunz JB, Rausch T, Bandapalli OR, Eilers J, Pechanska P, Schuessele S, Assenov Y, Stutz AM, Kirschner-Schwabe R, Hof J, Eckert C, von Stackelberg A, Schrappe M, Stanulla M, Koehler R, Avigad S, Elitzur S, Handgretinger R, Benes V, Weischenfeldt J, Korbel JO, Muckenthaler MU, Kulozik AE: Pediatric t cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation. Haematologica 2015, 100: 1442-1450

44. Diaz V, Peinado AB, Barba-Moreno L, Altamura S, Butragueno J, Gonzalez-Gross M, Alteheld B, Stehle P, Zapico AG, Muckenthaler MU, Gassmann M: Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin c and e. Physiol Rep 2015, 3

45. Gassmann M, Muckenthaler MU: Adaptation of iron requirement to hypoxic conditions at high altitude. J Appl Physiol 2015, 119: 1432-1440

46. Sommerburg O, Hammermann J, Lindner M, Stahl M, Muckenthaler M, Kohlmueller D, Happich M, Kulozik AE, Stopsack M, Gahr M, Hoffmann GF, Mall MA: Five years of experience with biochemical cystic fibrosis newborn screening based on irt/pap in Germany. Pediatr Pulmonol. 2015, 50: 655-664

47. Costa M, Cruz E, Oliveira S, Benes V, Ivacevic T, Silva MJ, Vieira I, Dias F, Fonseca S, Goncalves M, Lima M, Leitao C, Muckenthaler MU, Pinto J, Porto G: Lymphocyte gene expression signatures from patients and mouse models of hereditary hemochromatosis reveal a function of hfe as a negative regulator of cd8+ t-lymphocyte activation and differentiation in vivo. PLoS One 2015, 10: e0124246

48. Lenzhofer M, Schroedl F, Trost A, Kaser-Eichberger A, Wiedemann H, Strohmaier C, Hohensinn M, Strasser M, Muckenthaler MU, Grabner G, Aigner E, Reitsamer HA: Aqueous humor ferritin in hereditary hyperferritinemia cataract syndrome. Optom Vis Sci 2015, 92: 40-47

49. Guida C, Altamura S, Klein FA, Galy B, Boutros M, Ulmer AJ, Hentze MW, Muckenthaler MU: A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia. Blood 2015, 125: 2265-2275

50. Rathkolb B, Klempt M, Sabrautzki S, Michel D, Klaften M, Laufs J, Sedlmeier R, Hans W, Fuchs H, Muckenthaler MU, Horsch M, Campagna DR, Fleming M, Hrabe de Angelis M, Wolf E, Aigner B:Screen for alterations of iron related parameters in n-ethyl-n-nitrosourea-treated mice identified mutant lines with increased plasma ferritin levels. Biometals 2015, 28: 293-306

51. Altamura S, Bartsch P, Dehnert C, Maggiorini M, Weiss G, Theurl I, Muckenthaler MU, Mairbaurl H: Increased hepcidin levels in high-altitude pulmonary edema. J Appl Physiol 2015, 118: 292-298

52. Peiffer KH, Niemeyer M, Buslau A, Kohnen T, Muckenthaler MU, Zeuzem S, Sarrazin C: Iron deficiency anaemia and cataracts in a patient with haemochromatosis.Gut 2014, 63: 686, 98

53. Sommerburg O, Krulisova V, Hammermann J, Lindner M, Stahl M, Muckenthaler M, Kohlmueller D, Happich M, Kulozik AE, Votava F, Balascakova M, Skalicka V, Stopsack M, Gahr M, Macek M, Jr., Mall MA, Hoffmann GF: Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2014, 13: 15-23

54. Cario G, Rhein P, Mitlohner R, Zimmermann M, Bandapalli OR, Romey R, Moericke A, Ludwig WD, Ratei R, Muckenthaler MU, Kulozik AE, Schrappe M, Stanulla M, Karawajew L: High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol. Haematologica 2014, 99: 103-10

55. Ryan JD, Altamura S, Muckenthaler M, Crowe J: Reply: To PMID 22334511 Hepcidin as a predictor of treatment response in chronic hepatitis c infection. Hepatology 2014, 59: 1648-9

56. Mleczko-Sanecka K, Roche F, da Silva AR, Call D, D'Alessio F, Ragab A, Lapinski PE, Ummanni R, Korf U, Oakes C, Damm G, D'Alessandro LA, Klingmuller U, King PD, Boutros M, Hentze MW, Muckenthaler MU: Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood 2014, 123: 1574-85

57. Casanovas G, Banerji A, d'Alessio F, Muckenthaler MU, Legewie S: A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis. PLoS computational biology 2014, 10

58. Sonnweber T, Nachbaur D, Schroll A, Nairz M, Seifert M, Demetz E, Haschka D, Mitterstiller AM, Kleinsasser A, Burtscher M, Trubsbach S, Murphy AT, Wroblewski V, Witcher DR, Mleczko- Sanecka K, Vecchi C, Muckenthaler MU, Pietrangelo A, Theurl I, Weiss G: Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB. Gut 2014, 63: 1951-9

59. Hidmark A, Fleming T, Vittas S, Mendler M, Deshpande D, Groener JB, Muller BP, Reeh PW, Sauer SK, Pham M, Muckenthaler MU, Bendszus M, Nawroth PP: A new paradigm to understand and treat diabetic neuropathy. Experimental and clinical endocrinology & diabetes. Official journal, German Society of Endocrinology [and] German Diabetes Association 2014, 122: 201-7

60. Shochat C, Tal N, Gryshkova V, Birger Y, Bandapalli OR, Cazzaniga G, Gershman N, Kulozik AE, Biondi A, Mansour MR, Twizere JC, Muckenthaler MU, Ben-Tal N, Constantinescu SN, Bercovich D, Izraeli S: Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia. Blood 2014, 124: 106-10

61. Vinchi F, Muckenthaler MU, Da Silva MC, Balla G, Balla J, Jeney V: Atherogenesis and iron: from epidemiology to cellular level. Frontiers in pharmacology 2014, 5: 94

62. Magni S, Comani GB, Elli L, Vanessi S, Ballarini E, Nicolini G, Rusconi M, Castoldi M, Meneveri R, Muckenthaler MU, Bardella MT, Barisani D: miRNAs affect the expression of innate and adaptive immunity proteins in celiac disease. The American journal of gastroenterology 2014, 109: 1662-74

63. Altamura S, Kessler R, Grone HJ, Gretz N, Hentze MW, Galy B, Muckenthaler MU: Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload. Cell metabolism 2014, 20: 359-67

64. Muckenthaler MU: How mutant HFE causes hereditary hemochromatosis. Blood 2014, 124: 1212-3

65. Bandapalli OR, Schuessele S, Kunz JB, Rausch T, Stutz AM, Tal N, Geron I, Gershman N, Izraeli S, Eilers J, Vaezipour N, Kirschner-Schwabe R, Hof J, von Stackelberg A, Schrappe M, Stanulla M, Zimmermann M, Koehler R, Avigad S, Handgretinger R, Frismantas V, Bourquin JP, Bornhauser B, Korbel JO, Muckenthaler MU, Kulozik AE: The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse. Haematologica 2014, 99: e188-92

66. Steinbicker AU, Muckenthaler MU: Out of balance--systemic iron homeostasis in iron-related disorders. Nutrients 2013, 5: 3034-3061.

67. 95. Cozzi A, Santambrogio P, Privitera D, Broccoli V, Rotundo LI, Garavaglia B, Benz R, Altamura S, Goede JS, Muckenthaler MU, Levi S: Human l-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome. J Exp Med 2013; 210:1779-

1791.

68. Benesova K, Schaefer SM, Mall MA, Muckenthaler MU: Computerized image analysis of ironstained macrophages. Ann Hematol 2013; 92(9):1195-9

69. Lodrini M, Oehme I, Schroeder C, Milde T, Schier MC, Kopp-Schneider A, Schulte JH, Fischer M, De Preter K, Pattyn F, Castoldi M, Muckenthaler MU, Kulozik AE, Westermann F, Witt O, Deubzer HE: Mycn and hdac2 cooperate to repress mir-183 signaling in neuroblastoma. Nucleic Acids Res 2013; 41:6018-6033

70. Nairz M, Schleicher U, Schroll A, Sonnweber T, Theurl I, Ludwiczek S, Talasz H, Brandacher G, Moser PL, Muckenthaler MU, Fang FC, Bogdan C, Weiss G: Nitric oxide-mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in salmonella infection. J Exp Med 2013; 210:855-87

71. De Falco L, Sanchez M, Silvestri L, Kannengiesser C, Muckenthaler MU, Iolascon A, Gouya L, Camaschella C, Beaumont C: Iron refractory iron deficiency anemia. Haematologica 2013; 98:845-853.

72. Vujic Spasic M, Sparla R, Mleczko-Sanecka K, Migas MC, Breitkopf-Heinlein K, Dooley S, Vaulont S, Fleming RE, Muckenthaler MU: Smad6 and smad7 are co-regulated with hepcidin in mouse models of iron overload. Biochim Biophys Acta 2013; 1832:76-84

73. Luscieti S, Tolle G, Aranda J, Campos CB, Risse F, Moran E, Muckenthaler MU, Sanchez M: Novel mutations in the ferritin-l iron-responsive element that only mildly impair irp binding cause hereditary hyperferritinaemia cataract syndrome. Orphanet J Rare Dis 2013; 8:30

74. Lehmberg K, Grosse R, Muckenthaler MU, Altamura S, Nielsen P, Schmid H, Graubner U, Oyen F, Zeller W, Schneppenheim R, Janka GE: Administration of recombinant erythropoietin alone does not improve the phenotype in iron refractory iron deficiency anemia patients. Ann Hematol 2013; 92:387-394

75. Guo W, Bachman E, Li M, Roy CN, Blusztajn J, Wong S, Chan SY, Serra C, Jasuja R, Travison TG, Muckenthaler MU, Nemeth E, Bhasin S: Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells. Aging Cell 2013; 12:280-291

76. Casanovas G, Spasic MV, Casu C, Rivella S, Strelau J, Unsicker K, Muckenthaler MU: The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice. Haematologica 2013; 98:444-447

77. Bandapalli OR, Zimmermann M, Kox C, Stanulla M, Schrappe M, Ludwig WD, Koehler R, Muckenthaler MU, Kulozik AE: Notch1 activation clinically antagonizes the unfavorable effect of pten inactivation in bfm-treated children with precursor t-cell acute lymphoblastic leukemia. Haematologica 2013; 98:928-936

78. Millonig G, Ganzleben I, Peccerella T, Casanovas G, Brodziak-Jarosz L, Breitkopf-Heinlein K, Dick TP, Seitz HK, Muckenthaler MU, Mueller S: Sustained submicromolar h2o2 levels induce hepcidin via signal transducer and activator of transcription 3 (stat3). J Biol Chem 2012; 287:37472-37482

79. Benesova K, Vujic Spasic M, Schaefer SM, Stolte J, Baehr-Ivacevic T, Waldow K, Zhou Z, Klingmueller U, Benes V, Mall MA, Muckenthaler MU: Hfe deficiency impairs pulmonary neutrophil recruitment in response to inflammation. PLoS One 2012; 7:e39363

80. D'Alessio F, Hentze MW, Muckenthaler MU: The hemochromatosis proteins hfe, tfr2, and hjv form a membrane-associated protein complex for hepcidin regulation. J Hepatol 2012; 57:1052-1060

81. Castoldi M, Muckenthaler MU: Regulation of iron homeostasis by microRNAs. Cell Mol Life Sci 2012; 69:3945-3952

82. Gutierrez L, Vujic Spasic M, Muckenthaler MU, Lazaro FJ: Quantitative magnetic analysis reveals ferritin-like iron as the most predominant iron-containing species in the murine hfehaemochromatosis. Biochim Biophys Acta 2012; 1822:1147-1153

83. Ryan JD, Altamura S, Devitt E, Mullins S, Lawless MW, Muckenthaler MU, Crowe J: Pegylated interferon-alpha induced hypoferremia is associated with the immediate response to treatment in hepatitis c. Hepatology 2012; 56:492-500

84. Mueller C, Schrag M, Crofton A, Stolte J, Muckenthaler MU, Magaki S, Kirsch W: Altered serum iron and copper homeostasis predicts cognitive decline in mild cognitive impairment. J Alzheimers Dis 2012; 29:341-350

85. Shochat C, Tal N, Bandapalli OR, Palmi C, Ganmore I, te Kronnie G, Cario G, Cazzaniga G, Kulozik AE, Stanulla M, Schrappe M, Biondi A, Basso G, Bercovich D, Muckenthaler MU, Izraeli S: Gain-of-function mutations in interleukin-7 receptor-alpha (il7r) in childhood acute lymphoblastic leukemias. J Exp Med 2011; 208:901-908

86. Sanchez M, Galy B, Schwanhaeusser B, Blake J, Bahr-Ivacevic T, Benes V, Selbach M, Muckenthaler MU, Hentze MW: Iron regulatory protein-1 and -2: Transcriptome-wide definition of binding mrnas and shaping of the cellular proteome by iron regulatory proteins. Blood 2011; 118:e168-179

87. Rodrigues PN, Gomes SS, Neves JV, Gomes-Pereira S, Correia-Neves M, Nunes-Alves C, Stolte J, Sanchez M, Appelberg R, Muckenthaler MU, Gomes MS: Mycobacteria-induced anaemia revisited: A molecular approach reveals the involvement of nramp1 and lipocalin-2, but not of hepcidin. Immunobiology 2011; 216:1127-1134

88. Haghikia A, Missol-Kolka E, Tsikas D, Venturini L, Brundiers S, Castoldi M, Muckenthaler MU, Eder M, Stapel B, Thum T, Petrasch-Parwez E, Drexler H, Hilfiker-Kleiner D, Scherr M: Signal transducer and activator of transcription 3-mediated regulation of mir-199a-5p links cardiomyocyte and endothelial cell function in the heart: A key role for ubiquitin-conjugating enzymes. Eur Heart J 2011; 32:1287-1297

89. Castoldi M, Vujic Spasic M, Altamura S, Elmen J, Lindow M, Kiss J, Stolte J, Sparla R, D'Alessandro LA, Klingmuller U, Fleming RE, Longerich T, Grone HJ, Benes V, Kauppinen S, Hentze MW, Muckenthaler MU: The liver-specific microrna mir-122 controls systemic iron homeostasis in mice. J Clin Invest 2011; 121:1386-1396

90. Casanovas G, Swinkels DW, Altamura S, Schwarz K, Laarakkers CM, Gross HJ, Wiesneth M, Heimpel H, Muckenthaler MU: Growth differentiation factor 15 in patients with congenital dyserythropoietic anaemia (cda) type ii. J Mol Med (Berl) 2011; 89:811-81

91. Altamura S, D'Alessio F, Selle B, Muckenthaler MU: A novel TMPRSS6 mutation that prevents protease auto-activation causes IRIDA. Biochem J. 2010; 431(3):363-71

92. Vainshtein Y, Sanchez M, Brazma A, Hentze MW, Dandekar T, Muckenthaler MU: The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays. BMC Bioinformatics 2010; 11:112

93. Sommerburg O, Lindner M, Muckenthaler M, Kohlmueller D, Leible S, Feneberg R, Kulozik AE, Mall MA, Hoffmann GF: Initial evaluation of a biochemical cystic fibrosis newborn screening by sequential analysis of immunoreactive trypsinogen and pancreatitis-associated protein (IRT/PAP) as a strategy that does not involve DNA testing in a Northern European population. J Inherit Metab Dis 2010; 33(Suppl 2):S263-271

94. Mleczko-Sanecka K, Casanovas G, Ragab A, Breitkopf K, Muller A, Boutros M, Dooley S, Hentze MW, Muckenthaler MU: SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Blood 2010; 115(13):2657-2665

95. Millonig G, Muckenthaler MU, Mueller S: Hyperferritinaemia-cataract syndrome: worldwide mutations and phenotype of an increasingly diagnosed genetic disorder. Hum Genomics 2010; 4(4):250-262

96. Marro S, Chiabrando D, Messana E, Stolte J, Turco E, Tolosano E, Muckenthaler MU: Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter. Haematologica 2010; 95(8):1261-1268

97. Lopes TJ, Luganskaja T, Vujic Spasic M, Hentze MW, Muckenthaler MU, Schumann K, Reich JG: Systems analysis of iron metabolism: the network of iron pools and fluxes. BMC Syst Biol 2010; 4:112

98. Kox C, Zimmermann M, Stanulla M, Leible S, Schrappe M, Ludwig WD, Koehler R, Tolle G, Bandapalli OR, Breit S, Muckenthaler MU, Kulozik AE: The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function. Leukemia 2010; 24(12):2005-2013

99. Hentze MW, Muckenthaler MU, Galy B, Camaschella C: Two to tango: regulation of Mammalian iron metabolism. Cell 2010; 142(1):24-38

100. Remke M, Pfister S, Kox C, Toedt G, Becker N, Benner A, Werft W, Breit S, Liu S, Engel F, Wittmann A, Zimmermann M, Stanulla M, Schrappe M, Ludwig WD, Bartram CR, Radlwimmer B, Muckenthaler MU, Lichter P, Kulozik AE: High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response. Blood 2009; 114(5):1053-1062

101. Pfister S, Remke M, Castoldi M, Bai AH, Muckenthaler MU, Kulozik A, von Deimling A, Pscherer A, Lichter P, Korshunov A: Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes. Acta Neuropathol 2009; 117(4):457-464

102. Millonig G, Holzer MP, Tolle G, Auffarth GU, Muckenthaler MU, Seitz HK, Mueller S: [Hereditary hyperferritinemia cataract syndrome--the first family in Germany]. Z Gastroenterol 2009; 47(12):1211

103. Liu S, Breit S, Danckwardt S, Muckenthaler MU, Kulozik AE: Downregulation of Notch signaling by gamma-secretase inhibition can abrogate chemotherapy-induced apoptosis in T-ALL cell lines. Ann Hematol 2009; 88(7):613-621

104. Ibberson D, Benes V, Muckenthaler MU, Castoldi M: RNA degradation compromises the reliability of microRNA expression profiling. BMC Biotechnol 2009; 9:102

105. Casanovas G, Mleczko-Sanecka K, Altamura S, Hentze MW, Muckenthaler MU: Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD. J Mol Med 2009; 87(5):471-480

106. Bartz F, Kern L, Erz D, Zhu M, Gilbert D, Meinhof T, Wirkner U, Erfle H, Muckenthaler M, Pepperkok, Runz H: Identification of cholesterol-regulating genes by targeted RNAi screening. Cell Metab 2009; 10(1):63-75

107. Altamura S, Muckenthaler MU: Iron toxicity in diseases of aging: Alzheimer's disease, Parkinson's disease and atherosclerosis. J Alzheimers Dis 2009; 16(4):879-895

108. Altamura S, Kiss J, Blattmann C, Gilles W, Muckenthaler MU: SELDI-TOF MS detection of urinary hepcidin. Biochimie 2009; 91(10):1335-1338

109. Vujic Spasic M, Kiss J, Herrmann T, Galy B, Martinache S, Stolte J, Grone HJ, Stremmel W, Hentze MW, Muckenthaler MU: Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab 2008; 7(2):173-178

110. Verga Falzacappa MV, Casanovas G, Hentze MW, Muckenthaler MU: A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. J Mol Med 2008; 86(5):531-540

111. Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J, Engelhardt S: MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008; 456(7224):980-984

112. Muckenthaler MU, Galy B, Hentze MW: Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu Rev Nutr 2008; 28:197-213

113. Muckenthaler MU: Fine tuning of hepcidin expression by positive and negative regulators. Cell Metab 2008; 8(1):1-3

114. Castoldi M, Schmidt S, Benes V, Hentze MW, Muckenthaler MU: miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes. Nat Protoc 2008; 3(2):321-329

115. Braliou GG, Verga Falzacappa MV, Chachami G, Casanovas G, Muckenthaler MU, Simos G: 2-Oxoglutarate-dependent oxygenases control hepcidin gene expression. J Hepatol 2008; 48(5):801-

810

116. Vujic Spasic M, Kiss J, Herrmann T, Kessler R, Stolte J, Galy B, Rathkolb B, Wolf E, Stremmel W, Hentze MW, Muckenthaler MU: Physiologic systemic iron metabolism in mice deficient for duodenal Hfe. Blood 2007; 109(10):4511-4517

117. Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU: STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 2007; 109(1):353-358

118. Venturini L, Battmer K, Castoldi M, Schultheis B, Hochhaus A, Muckenthaler MU, Ganser A, Eder M, Scherr M: Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+cells. Blood 2007; 109(10):4399-4405

119. Sanchez M, Galy B, Muckenthaler MU, Hentze MW: Iron-regulatory proteins limit hypoxiainducible factor-2alpha expression in iron deficiency. Nat Struct Mol Biol 2007; 14(5):420-426

120. Sanchez M, Galy B, Hentze MW, Muckenthaler MU: Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays. Nat Protoc 2007; 2(8):2033-2042

121. Percy MJ, Sanchez M, Swierczek S, McMullin MF, Mojica-Henshaw MP, Muckenthaler MU, Prchal JT, Hentze MW: Is congenital secondary erythrocytosis/polycythemia caused by activating mutations within the HIF-2 alpha iron-responsive element? Blood 2007; 110(7):2776-2777

122. Marro S, Barisani D, Chiabrando D, Fagoonee S, Muckenthaler MU, Stolte J, Meneveri R, Haile D, Silengo L, Altruda F, Altruda F, Tolosano E: Lack of haptoglobin affects iron transport across duodenum by modulating ferroportin expression. Gastroenterology 2007; 133(4):1261-1271

123. Ludwiczek S, Theurl I, Muckenthaler MU, Jakab M, Mair SM, Theurl M, Kiss J, Paulmichl M, Hentze MW, Ritter M, Weiss G: Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat Med 2007; 13(4):448-454

124. Fillebeen C, Muckenthaler M, Andriopoulos B, Bisaillon M, Mounir Z, Hentze MW, Koromilas AE, Pantopoulos K: Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells. J Hepatol 2007; 47(1):12-22

125. Castoldi M, Benes V, Hentze MW, Muckenthaler MU: miChip: a microarray platform for expression profiling of microRNAs based on locked nucleic acid (LNA) oligonucleotide capture probes. Methods 2007; 43(2):146-152

126. Sanchez M, Galy B, Dandekar T, Bengert P, Vainshtein Y, Stolte J, Muckenthaler MU, Hentze MW: Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'- untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. J Biol Chem 2006; 281(32):22865-22874

127. Mok H, Mlodnicka AE, Hentze MW, Muckenthaler M, Schumacher A: The molecular circuitry regulating the switch between iron deficiency and overload in mice. J Biol Chem 2006, 281(12):7946-7951.

128. Castoldi M, Schmidt S, Benes V, Noerholm M, Kulozik AE, Hentze MW, Muckenthaler MU: A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA). RNA 2006; 12(5):913-920

129. Breit S, Stanulla M, Flohr T, Schrappe M, Ludwig WD, Tolle G, Happich M, Muckenthaler MU, Kulozik AE: Activating NOTCH1 mutations predict favorable early treatment response and longterm outcome in childhood precursor T-cell lymphoblastic leukemia. Blood 2006; 108(4):1151-1157

130. Auclair S, Feillet-Coudray C, Coudray C, Schneider S, Muckenthaler MU, Mazur A: Mild copper deficiency alters gene expression of proteins involved in iron metabolism. Blood Cells Mol Dis 2006; 36(1):15-20

131. Verga Falzacappa MV, Muckenthaler MU: Hepcidin: iron-hormone and anti-microbial peptide. Gene 2005; 364:37-44

132. Galy B, Ferring D, Minana B, Bell O, Janser HG, Muckenthaler M, Schumann K, Hentze MW: Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Blood 2005; 106(7):2580-2589

133. Fillebeen C, Rivas-Estilla AM, Bisaillon M, Ponka P, Muckenthaler M, Hentze MW, Koromilas AE, Pantopoulos K: Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus. J Biol Chem 2005; 280(10):9049-9057

134. Eber S, Muckenthaler M: Eisenmangelanämie - und Anämie chronischer Erkrankungen im Kindesalter. Kinder und Jugendarzt 2005; 36:31-41

135. Bonnah RA, Hoelter J, Steeghs L, Enns CA, So M, Muckenthaler MU: Lipooligosaccharideindependent alteration of cellular homeostasis in Neisseria meningitidis-infected epithelial cells. Cell Microbiol 2005; 7(6):869-885

136. Wang J, Chen G, Muckenthaler M, Galy B, Hentze MW, Pantopoulos K: Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity. Mol Cell Biol 2004, 24(3):954-965

137. Roy CN, Custodio AO, de Graaf J, Schneider S, Akpan I, Montross LK, Sanchez M, Gaudino A, Hentze MW, Andrews NC, Muckenthaler MU: An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet 2004, 36(5):481-485.

138. Muckenthaler MU, Rodrigues P, Macedo MG, Minana B, Brennan K, Cardoso EM, Hentze MW, de Sousa M: Molecular analysis of iron overload in beta2-microglobulin-deficient mice. Blood Cells Mol Dis 2004, 33(2):125-131

139. Herrmann T, Muckenthaler M, van der Hoeven F, Brennan K, Gehrke SG, Hubert N, Sergi C, Grone HJ, Kaiser I, Gosch I, Volkmann M, Riedel HD, Hentze MW, Stewart AF, Stremmel W: Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin. J Mol Med 2004, 82(1):39-48

140. Hentze MW, Muckenthaler MU, Andrews NC: Balancing acts: molecular control of mammalian iron metabolism. Cell 2004, 117(3):285-297.

141. Breit S, Nees M, Schaefer U, Pfoersich M, Hagemeier C, Muckenthaler M, Kulozik AE: Impact of pre-analytical handling on bone marrow mRNA gene expression. Br J Haematol 2004, 126(2):231-243

142. Bonnah RA, Muckenthaler MU, Carlson H, Minana B, Enns CA, Hentze MW, So M: Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis. Cell Microbiol 2004, 6(5):473-484

143. Thompson K, Menzies S, Muckenthaler M, Torti FM, Wood T, Torti SV, Hentze MW, Beard J, Connor J: Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress. J Neurosci Res 2003, 71(1):46-63

144. Muckenthaler M, Roy CN, Custodio AO, Minana B, deGraaf J, Montross LK, Andrews NC, Hentze MW: Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet 2003, 34(1):102-107

145. Muckenthaler M, Richter A, Gunkel N, Riedel D, Polycarpou-Schwarz M, Hentze S, Falkenhahn M, Stremmel W, Ansorge W, Hentze MW: Relationships and distinctions in iron-regulatory networks responding to interrelated signals. Blood 2003, 101(9):3690-3698

146. Benes V, Muckenthaler M: Standardization of protocols in cDNA microarray analysis. Trends Biochem Sci 2003, 28(5):244-249

147. Richter A, Schwager C, Hentze S, Ansorge W, Hentze MW, Muckenthaler M: Comparison of fluorescent tag DNA labeling methods used for expression analysis by DNA microarrays.Biotechniques 2002, 33(3):620-628, 630

148. Muckenthaler M: Biochips. BiomedPark 2000(1):10-14

149. Riedel HD, Muckenthaler MU, Gehrke SG, Mohr I, Brennan K, Herrmann T, Fitscher BA, Hentze MW, Stremmel W: HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells. Blood 1999, 94(11):3915-3921

150. Preiss T, Muckenthaler M, Hentze MW: Poly(A)-tail-promoted translation in yeast: implications for translational control. RNA 1998, 4(11):1321-1331

151. Muckenthaler M, Gunkel N, Frishman D, Cyrklaff A, Tomancak P, Hentze MW: Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans. Eur J Biochem 1998,

254(2):230-237

152. Muckenthaler M, Gray NK, Hentze MW: IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F. Mol Cell 1998, 2(3):383-388

153. Korner CG, Wormington M, Muckenthaler M, Schneider S, Dehlin E, Wahle E: The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes. EMBO J 1998, 17(18):5427-5437

154. Andersen O, Pantopoulos K, Kao HT, Muckenthaler M, Youson JH, Pieribone V: Regulation of iron metabolism in the sanguivore lamprey Lampetra fluviatilis--molecular cloning of two ferritin subunits and two iron-regulatory proteins (IRP) reveals evolutionary conservation of the ironregulatory element (IRE)/IRP regulatory system. Eur J Biochem 1998, 254(2):223-229

155. Muckenthaler M, Hentze MW: Mechanisms for posttranscriptional regulation by iron-responsive elements and iron regulatory proteins. Prog Mol Subcell Biol 1997, 18:93-115

156. Muckenthaler M, Gunkel N, Stripecke R, Hentze MW: Regulated poly(A) tail shortening in somatic cells mediated by cap-proximal translational repressor proteins and ribosome association. RNA 1997, 3(9):983-995

157. Gunkel N, Braddock M, Thorburn AM, Muckenthaler M, Kingsman AJ, Kingsman SM: Promoter control of translation in Xenopus oocytes. Nucleic Acids Res 1995, 23(3):405-412

158. Braddock M, Muckenthaler M, White MR, Thorburn AM, Sommerville J, Kingsman AJ, Kingsman SM: Intron-less RNA injected into the nucleus of Xenopus oocytes accesses a regulated translation control pathway. Nucleic Acids Res 1994, 22(24):5255-5264

159. Braddock M, Cannon P, Muckenthaler M, Kingsman AJ, Kingsman SM: Inhibition of human immunodeficiency virus type 1 Tat-dependent activation of translation in Xenopus oocytes by the benzodiazepine Ro24-7429 requires trans-activation response element loop sequences. J Virol

1994, 68(1):25-33

160. Baker B, Muckenthaler M, Vives E, Blanchard A, Braddock M, Nacken W, Kingsman AJ, Kingsman SM: Identification of a novel HIV-1 TAR RNA bulge binding protein. Nucleic Acids Res 1994, 22(16):3365-3372

161. Muckenthaler M, Gunkel N, Levantis P, Broadhurst K, Goh B, Colvin B, Forster G, Jackson GG, Oxford JS: Sequence analysis of an HIV-1 isolate which displays unusually high-level AZT resistance in vitro. J Med Virol 1992, 36(2):79-83

1. Castoldi M, Benes V, Muckenthaler M: How to assay miRNA expression - a technology guide. In: Regulation of Gene Expression by Small RNAs. Edited by Rajesh K, Rossi J, Gaur R: CRC Press; 2009: 215-240.

2. Muckenthaler M, Preiss T: Mechanismen der Translationskontrolle in Eukaryonten. In: Grundlagender Molekularen Medizin. Edited by Ruckpaul K, Ganten D. Heidelberg: Springer Verlag; 2008: 139-158.

3. Muckenthaler M, Kulozik A: Anämie chronischer Erkrankungen. In: Pädiatrische Hämatologie und Onkologie. Edited by Gadner H, Gaedicke G, Niemeyer C, Ritter J. Heidelberg: Springer Verlag; 2006:186-191.

4. Muckenthaler M, Preiss T: Translational Control in Eukaryotes. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Edited by Ganten D, Ruckpaul K. Heidelberg: Springer Verlag; 2004.

5. Muckenthaler M, Preiss T: Mechanismen der Transkriptionskontrolle in Eukarynoten. In: Grundlagender Molekularen Medizin. Edited by Ruckpaul K, Ganten D, vol. 1. Heidelberg: Springer Verlag; 2003:152-180.

6. Muckenthaler M, Hentze MW: Mechanisms for Posttranscriptional Regulation by Iron- Responsive Elements and Iron Regulatory Proteins. In: Progress in Molecular and  Subcellular Biology. Edited by Jeanteur, vol. 18. Heidelberg: Springer Verlag; 1996: 93-115.