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Test ID: IgG subclass panel
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IgG subclass panel
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IgG subclass panel
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Useful For
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The investigation of immunodeficiency and IgG4-related disease
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Method name and description
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Clinical information
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Immunoglobulin G is a component of the immune system and has a vital role in maintenance of immunity. Deficiencies of one or more of the IgG subclasses (IgG1, IgG2, IgG3, IgG4) can result in the development of immunodeficiency. Conversely, increased levels of IgG4 is associated with IgG4-related disease, which is an autoimmune condition often presenting as autoimmune pancreatitis.
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Aliases
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IgG subclasses
IgGSC
IgG4
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Specimen type / Specimen volume / Specimen container
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Specimen type: Blood (serum).
Specimen Volume: 1.5 mL serum.
Specimen container: gel tube (yellow top) or red top tube.
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Collection instructions / Special Precautions / Timing of collection
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Blood samples should be collected by venipuncture, allowed to clot naturally and the serum separated as soon as possible to prevent hemolysis.
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Relevant clinical information to be provided
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Presenting clinical signs and symptoms
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Storage and transport instructions
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Blood samples can be transported at ambiant temperature as quickly as possible.
Separated serum samples may be stored for up to 8 days at 2-8°C.
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Specimen Rejection Criteria
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Insufficient samples.
Microbially contaminated, hemolyzed and highly lipemic serum and samples containing particulate matter should not be used.
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Biological reference intervals and clinical decision values
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IgG1
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Age
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Range (mg/L)
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0- 2 years
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1940 - 8420
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2-4 years
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3150 - 9450
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4- 6 years
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3060 - 9450
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6-8 years
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2880 - 9180
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8-10 years
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4320 -10200
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10-12 years
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4230 -10600
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12- 14 years
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3420 -11500
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14-18 years
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3150 - 8550
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Adult range >18 years
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3824 - 9286
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IgG2
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Age
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Range (mg/L)
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0- 2 years
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225 -3000
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2-4 years
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360 -2250
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4- 6 years
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605 -3450
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6-8 years
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440 -3750
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8-10 years
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720 -4300
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10-12 years
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760 -3550
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12- 14 years
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1000 -4550
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14-18 years
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640 - 4950
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Adult range > 18 years
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2418 - 7003
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IgG3
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Age
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Range (mg/L)
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0- 2 years
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186 – 853
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2-4 years
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173 -676
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4- 6 years
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99 -1221
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6-8 years
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155 - 853
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8-10 years
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127 -853
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10-12 years
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173 - 1730
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12- 14 years
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283 -1250
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14-18 years
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230 - 1960
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Adult range > 18 years
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218.2 – 1760.6
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IgG4
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Age
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Range (mg/L)
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0- 2 years
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5 - 784
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2-4 years
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10 -537
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4- 6 years
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18 -1125
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6-8 years
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4 - 992
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8-10 years
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19 -932
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10-12 years
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16 -1150
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12- 14 years
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37 -1360
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14-18 years
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110 -1570
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Adult range > 18 years
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39.2 - 864
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Turnaround time / Days and times test performed / Specimen retention time
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Turnaround time: 10 working days.
Days and times test performed: Once every two weeks
Specimen retention time: 30 days.
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