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Test ID: Waldenstroms Macroglobulinemia by FISH
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Waldenstroms Macroglobulinemia by FISH
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Waldenstroms Macroglobulinemia (WM) performed by FISH Test.
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Useful For
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Waldenstroms Macroglobulinemia (WM) comprises of 1–2% of hematologic cancer which is an inactive and serious B-cell neoplasm characterized by the aggregation of lymphoplasmacytic cells within the bone marrow and defined by the intensive production of Monoclonal Immunoglobulin M (IgM) protein.
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Method name and description
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Interphase Fluorescence In Situ Hybridization (I-FISH) study
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Reporting name
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Waldenstroms Macroglobulinemia by FISH.
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Specimen type / Specimen volume / Specimen container
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1. Specimen Type: Blood/Leukemic Blood
Container/Tube: Green top (sodium heparin)
Specimen Volume: 2-6 mL (Varies depending on the WBC-Count).
(Adult - 3-6 mL ,Child - 2 mL, Infant - 2 mL)
2. Specimen Type: Bone marrow
Container/Tube: Bone Marrow Transport Media
Specimen Volume: 1-3 mL (Varies depending on the WBC-Count).
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Collection instructions / Special Precautions / Timing of collection
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Sunday-Wednesday 7:00-14:00
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Storage and transport instructions
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Specimen Rejection Criteria
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Consistent with Diagnostic Genomic Division policies
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Factors affecting test performance and result interpretation
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WM patients require Cytogenetic studies as a mandatory test in order to report chromosomal abnormalities. Screening chromosome observations involving IGH (14q32), trisomy 12 and deletion of 6q. While the FISH test acts as a conjugate to monitor and analyze IGH of immunoglobulin heavy chain (IgH)with IGH rearrangements in WM patients.
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Turnaround time / Days and times test performed / Specimen retention time
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