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Test ID: Beta 2 Microglobulin (B2MG)
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Beta 2 Microglobulin (B2MG)
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Useful For
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To monitor prognosis of certain cancers like multiple myeloma and to assess renal tubular disorders
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Method name and description
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Immunoturbidimetric assay performed on the Roche cobas c-systems. Latex‑bound anti‑β2‑microglobulin antibodies react with antigen from the sample to form antigen/antibody complexes which are determined turbidimetrically after agglutination.
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Clinical information
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B2MG is a low‑molecular‑weight protein rapidly filtered through the renal glomeruli. B2MG serum concentrations are increased in autoimmune diseases, inflammation, in liver disease, in some malignancies such as myeloma, especially hematologic malignancies associated with B-lymphocyte lineage. Furthermore, patients with renal failure have a large increase in circulating serum levels because glomerular filtration is the primary clearance mechanism.
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Specimen type / Specimen volume / Specimen container
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Specimen type: Serum, Plasma
Minimum volume of sample: 1 mL
Serum: Plain tube (red or yellow top)
Plasma: Li‑heparin tube
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Collection instructions / Special Precautions / Timing of collection
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Collect blood by standard venipuncture techniques as per specimen requirements. When processing samples in primary tubes (sample collection systems), follow the instructions of the tube manufacturer.
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Storage and transport instructions
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Storage: 3 days at 2-8°C
3 days at 15 – 25°C
6 months at ‑20 °C (± 5 °C)
Transport: 2-25°C
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Specimen Rejection Criteria
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Grossly hemolyzed, icteric and lipemic samples, wrong collection container, insufficient sample.
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Biological reference intervals and clinical decision values
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0 to 60 years: 0.8 – 2.4 mg/L
>60 years: ≤ 3.0 mg/L
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Turnaround time / Days and times test performed / Specimen retention time
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Daily (24/7)
Turn-around time:
Routine: One working day
Specimen Retention: 4 days
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