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Test ID: T‐Cell Acute Lymphoblastic Leukemia Panel by FISH
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T‐Cell Acute Lymphoblastic Leukemia Panel by FISH
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T‐Cell Acute Lymphoblastic Leukemia Panel by FISH
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Useful For
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This test is performed to identify abnormal neoplastic clones associated with T-cell Acute Lymphoblastic Leukemia (T-ALL).
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Method name and description
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Interphase Fluorescence In Situ Hybridization (I-FISH) Study
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Specimen type / Specimen volume / Specimen container
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1. Specimen Type: Blood/Leukemic Blood
Container/Tube: Green top (sodium heparin)
Specimen Volume: 2-6 mL (Varies depending on the WBC-Count)
(Adult - 3-6 mL ,Child - 2 mL, Infant - 2 mL)
2. Specimen Type: Bone marrow
Container/Tube: Bone Marrow Transport Media
Specimen Volume: 1-3 mL (Varies depending on the WBC-Count)
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Collection instructions / Special Precautions / Timing of collection
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Sunday-Wednesday 7:00 -14:00
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Storage and transport instructions
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Specimen Rejection Criteria
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Consistent with Diagnostic Genomic division policies.
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Factors affecting test performance and result interpretation
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The FISH Panel is designed using the targets of the most common probes such as TRA/D, MLL, CEP9/CDKN2A and BCR/ABL1 to identify prognostically significant anomalies in T-ALL.
The FISH test acts as a useful adjunct to complete chromosome studies, assessing the progression, relapse in correlation with karyotyping.
One predictive marker, amplification of the ABL1 gene region, has been observed in a few T-ALL patients, and these patients may be responsive to targeted tyrosine kinase inhibitors.
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Turnaround time / Days and times test performed / Specimen retention time
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