|
Test ID: Carbamazepine
|
|
Carbamazepine Level
|
|
|
|
Useful For
|
Monitoring therapy , determining compliance and assessing toxicity.
|
|
Method name and description
|
Kinetic interaction of microparticles in solution (KIMS) as measured by changes in light transmission on the Roche cobas c-systems. Biotinylated drug hapten attached to streptavidin coated latex beads serves as the binding partner to anti-carbamazepine antibody. A competitive reaction to a limited amount of specific anti-carbamazepine antibody takes place between the latex bound hapten and free carbamazepine in the serum sample. A decrease in the apparent signal is proportional to the amount of drug present in the sample.
|
|
Clinical information
|
Carbamazepine is an anticonvulsant drug used in particular for the treatment of trigeminal neuralgia, all forms of partial epilepsy, generalized tonic‑clonic seizures, and simple and complex partial seizures.The specific mechanism of carbamazepine is proposed as a depressant action on transmission through the nucleus ventralis anterior of the thalamus.(Roche Cobas TDM Carbamazepine Gen.4 package insert).
|
|
|
Specimen type / Specimen volume / Specimen container
|
Specimen type: Serum, Plasma
Minimum volume of sample: 1 mL
Serum: Plain tube (red or yellow top)
Plasma: Li‑heparin tube tube
|
|
Collection instructions / Special Precautions / Timing of collection
|
Collect blood by standard venipuncture techniques as per specimen requirements. When processing samples in primary tubes (sample collection systems), follow the instructions of the tube manufacturer.
|
|
Storage and transport instructions
|
Storage: 7 days capped at 2-8°C
2 days capped at 20 – 25°C
4 weeks capped at ‑20 °C (± 5 °C)
Transport: 2-25°C
|
|
Specimen Rejection Criteria
|
Grossly hemolyzed, icteric and lipemic samples, wrong collection container, insufficient sample.
|
|
|
Biological reference intervals and clinical decision values
|
Therapeutic range: 16.9 - 50.8 umol/L
|
|
Turnaround time / Days and times test performed / Specimen retention time
|
Daily (24/7)
Turn-around time:
STAT: 1 hour
Routine: One working day
Specimen Retention: 4 days
|
|
|
