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Test ID: VDRL Screen CSF
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VDRL Antigen
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Useful For
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Qulitative and semi quantitative non-treponemal flocculation test for the detection of reagin antibodies in human CSF.
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Method name and description
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Aliases
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Neurosyphilis, Congenital syphilis
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Specimen type / Specimen volume / Specimen container
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Specimen type: CSF
Specimen volume: 1-2 mL
Specimen container: Sterile container
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Collection instructions / Special Precautions / Timing of collection
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C Collection by lumbar puncture as per organization guidelines
No special precautions / No timing of collection
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Storage and transport instructions
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Maintain specimen at 2-8°C
The specimens should be transported to Virology Section in cold box immediately
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Specimen Rejection Criteria
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Quantity of sample not sufficient
Mixed with blood
Wrong container
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Biological reference intervals and clinical decision values
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No reference value
Non-Reactive / Reactive with titer 1:1, 1:2, 1:4, 1:8 …..etc.
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Factors affecting test performance and result interpretation
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- Biological false positive reactions can occur with non-treponemal tests in persons with abuse drugs, disease such as lupus erythematous, mononucleosis, malaria, leprosy or viral pneumonia or have recently been immunized.
- Cross reaction may occur with other treponemal infections, such as yaws, pinta, bejel, or siti.
- Prozone reactions may occur in which reactivity with undiluted sample is inhibited. The prozone phenomenon often gives weakly reactive or rough non-reactive results in the qualitative test.
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Turnaround time / Days and times test performed / Specimen retention time
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Turnaround time: within 7 days
Days and times test performed: Twice a week
Specimen retention time: 1 week.
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